| Full name: pleckstrin and Sec7 domain containing 4 | Alias Symbol: TIC|EFA6B | ||
| Type: protein-coding gene | Cytoband: 2q14.1 | ||
| Entrez ID: 23550 | HGNC ID: HGNC:19096 | Ensembl Gene: ENSG00000125637 | OMIM ID: 614442 |
| Drug and gene relationship at DGIdb | |||
Expression of PSD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSD4 | 23550 | 236616_at | 0.0142 | 0.9920 | |
| GSE20347 | PSD4 | 23550 | 203317_at | -0.2581 | 0.0267 | |
| GSE23400 | PSD4 | 23550 | 203317_at | -0.0668 | 0.3308 | |
| GSE26886 | PSD4 | 23550 | 236616_at | -0.3882 | 0.2581 | |
| GSE29001 | PSD4 | 23550 | 203317_at | -0.3308 | 0.1357 | |
| GSE38129 | PSD4 | 23550 | 203317_at | -0.1313 | 0.4211 | |
| GSE45670 | PSD4 | 23550 | 236616_at | 0.1679 | 0.3871 | |
| GSE53622 | PSD4 | 23550 | 15644 | -0.0973 | 0.1864 | |
| GSE53624 | PSD4 | 23550 | 15644 | -0.1588 | 0.0308 | |
| GSE63941 | PSD4 | 23550 | 236616_at | 1.6791 | 0.0120 | |
| GSE77861 | PSD4 | 23550 | 236616_at | -0.0927 | 0.6421 | |
| GSE97050 | PSD4 | 23550 | A_33_P3312504 | 0.7489 | 0.1693 | |
| SRP007169 | PSD4 | 23550 | RNAseq | -1.2628 | 0.0033 | |
| SRP008496 | PSD4 | 23550 | RNAseq | -0.6913 | 0.0142 | |
| SRP064894 | PSD4 | 23550 | RNAseq | -0.5841 | 0.0028 | |
| SRP133303 | PSD4 | 23550 | RNAseq | -0.2960 | 0.1637 | |
| SRP159526 | PSD4 | 23550 | RNAseq | -1.1144 | 0.0030 | |
| SRP193095 | PSD4 | 23550 | RNAseq | -0.2680 | 0.0499 | |
| SRP219564 | PSD4 | 23550 | RNAseq | -0.4636 | 0.5074 | |
| TCGA | PSD4 | 23550 | RNAseq | -0.1491 | 0.0734 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by PSD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSD4 | 23550 | 7 | 2 | 21 | |
| GSE20123 | PSD4 | 23550 | 7 | 2 | 21 | |
| GSE43470 | PSD4 | 23550 | 3 | 1 | 39 | |
| GSE46452 | PSD4 | 23550 | 1 | 4 | 54 | |
| GSE47630 | PSD4 | 23550 | 6 | 0 | 34 | |
| GSE54993 | PSD4 | 23550 | 0 | 6 | 64 | |
| GSE54994 | PSD4 | 23550 | 8 | 3 | 42 | |
| GSE60625 | PSD4 | 23550 | 0 | 3 | 8 | |
| GSE74703 | PSD4 | 23550 | 3 | 1 | 32 | |
| GSE74704 | PSD4 | 23550 | 3 | 2 | 15 | |
| TCGA | PSD4 | 23550 | 31 | 6 | 59 |
Total number of gains: 69; Total number of losses: 30; Total Number of normals: 389.
Somatic mutations of PSD4:
Generating mutation plots.
Highly correlated genes for PSD4:
Showing top 20/208 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSD4 | SLC27A4 | 0.726565 | 3 | 0 | 3 |
| PSD4 | ANXA2 | 0.657149 | 7 | 0 | 6 |
| PSD4 | LPAR5 | 0.654075 | 6 | 0 | 5 |
| PSD4 | RHOF | 0.641341 | 4 | 0 | 3 |
| PSD4 | PRDX5 | 0.636266 | 3 | 0 | 3 |
| PSD4 | JUP | 0.630103 | 9 | 0 | 8 |
| PSD4 | GPR87 | 0.625672 | 6 | 0 | 4 |
| PSD4 | USP43 | 0.612563 | 5 | 0 | 4 |
| PSD4 | S100A11 | 0.611743 | 8 | 0 | 5 |
| PSD4 | CHMP4C | 0.609514 | 3 | 0 | 3 |
| PSD4 | GSTP1 | 0.609179 | 6 | 0 | 4 |
| PSD4 | GNA15 | 0.60758 | 10 | 0 | 9 |
| PSD4 | FGFBP1 | 0.607285 | 7 | 0 | 7 |
| PSD4 | VDR | 0.606584 | 6 | 0 | 4 |
| PSD4 | DMKN | 0.603014 | 4 | 0 | 3 |
| PSD4 | PRR32 | 0.602499 | 3 | 0 | 3 |
| PSD4 | SYTL1 | 0.600108 | 4 | 0 | 4 |
| PSD4 | UNC93B1 | 0.597176 | 4 | 0 | 3 |
| PSD4 | S100A16 | 0.593349 | 4 | 0 | 3 |
| PSD4 | S100A2 | 0.592895 | 7 | 0 | 4 |
For details and further investigation, click here
