| Full name: tenascin C | Alias Symbol: TN|MGC167029 | ||
| Type: protein-coding gene | Cytoband: 9q33.1 | ||
| Entrez ID: 3371 | HGNC ID: HGNC:5318 | Ensembl Gene: ENSG00000041982 | OMIM ID: 187380 |
| Drug and gene relationship at DGIdb | |||
TNC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of TNC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNC | 3371 | 201645_at | 1.0767 | 0.3460 | |
| GSE20347 | TNC | 3371 | 201645_at | 1.5086 | 0.0078 | |
| GSE23400 | TNC | 3371 | 201645_at | 1.9304 | 0.0000 | |
| GSE26886 | TNC | 3371 | 201645_at | 3.5098 | 0.0000 | |
| GSE29001 | TNC | 3371 | 201645_at | 1.5520 | 0.0121 | |
| GSE38129 | TNC | 3371 | 201645_at | 1.4634 | 0.0003 | |
| GSE45670 | TNC | 3371 | 201645_at | 1.3525 | 0.0762 | |
| GSE53622 | TNC | 3371 | 71191 | 1.6430 | 0.0000 | |
| GSE53624 | TNC | 3371 | 71191 | 1.8578 | 0.0000 | |
| GSE63941 | TNC | 3371 | 201645_at | -3.0742 | 0.0615 | |
| GSE77861 | TNC | 3371 | 201645_at | 2.6021 | 0.0095 | |
| GSE97050 | TNC | 3371 | A_23_P157865 | 1.7608 | 0.0631 | |
| SRP007169 | TNC | 3371 | RNAseq | 6.4126 | 0.0000 | |
| SRP008496 | TNC | 3371 | RNAseq | 6.4323 | 0.0000 | |
| SRP064894 | TNC | 3371 | RNAseq | 2.1928 | 0.0000 | |
| SRP133303 | TNC | 3371 | RNAseq | 2.3634 | 0.0000 | |
| SRP193095 | TNC | 3371 | RNAseq | 3.4414 | 0.0000 | |
| SRP219564 | TNC | 3371 | RNAseq | 1.3437 | 0.0742 | |
| TCGA | TNC | 3371 | RNAseq | 0.5581 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by TNC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNC | 3371 | 5 | 10 | 15 | |
| GSE20123 | TNC | 3371 | 5 | 10 | 15 | |
| GSE43470 | TNC | 3371 | 4 | 3 | 36 | |
| GSE46452 | TNC | 3371 | 6 | 13 | 40 | |
| GSE47630 | TNC | 3371 | 3 | 16 | 21 | |
| GSE54993 | TNC | 3371 | 3 | 3 | 64 | |
| GSE54994 | TNC | 3371 | 9 | 11 | 33 | |
| GSE60625 | TNC | 3371 | 0 | 0 | 11 | |
| GSE74703 | TNC | 3371 | 4 | 3 | 29 | |
| GSE74704 | TNC | 3371 | 2 | 7 | 11 | |
| TCGA | TNC | 3371 | 27 | 21 | 48 |
Total number of gains: 68; Total number of losses: 97; Total Number of normals: 323.
Somatic mutations of TNC:
Generating mutation plots.
Highly correlated genes for TNC:
Showing top 20/1048 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNC | ALPK2 | 0.803189 | 3 | 0 | 3 |
| TNC | XPR1 | 0.760832 | 7 | 0 | 7 |
| TNC | TGFBI | 0.751868 | 12 | 0 | 12 |
| TNC | COL5A2 | 0.748702 | 12 | 0 | 11 |
| TNC | LOXL2 | 0.738406 | 11 | 0 | 11 |
| TNC | PTHLH | 0.73713 | 12 | 0 | 12 |
| TNC | VMP1 | 0.733818 | 4 | 0 | 4 |
| TNC | COL5A1 | 0.720609 | 13 | 0 | 12 |
| TNC | SCYL1 | 0.715214 | 4 | 0 | 4 |
| TNC | PLAU | 0.714555 | 12 | 0 | 11 |
| TNC | INHBA | 0.712121 | 12 | 0 | 11 |
| TNC | AHR | 0.708889 | 10 | 0 | 10 |
| TNC | FAP | 0.704863 | 11 | 0 | 10 |
| TNC | WDR54 | 0.703871 | 7 | 0 | 5 |
| TNC | MFAP2 | 0.699718 | 12 | 0 | 11 |
| TNC | STIM2 | 0.699291 | 4 | 0 | 4 |
| TNC | ENAH | 0.698665 | 11 | 0 | 11 |
| TNC | LEPR | 0.69758 | 3 | 0 | 3 |
| TNC | VCAN | 0.695486 | 13 | 0 | 10 |
| TNC | COL1A1 | 0.695016 | 12 | 0 | 11 |
For details and further investigation, click here
