| Full name: short stature homeobox 2 | Alias Symbol: SHOT|OG12X|OG12 | ||
| Type: protein-coding gene | Cytoband: 3q25.32 | ||
| Entrez ID: 6474 | HGNC ID: HGNC:10854 | Ensembl Gene: ENSG00000168779 | OMIM ID: 602504 |
| Drug and gene relationship at DGIdb | |||
Expression of SHOX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHOX2 | 6474 | 210134_x_at | 0.1298 | 0.6496 | |
| GSE20347 | SHOX2 | 6474 | 210134_x_at | 0.0597 | 0.4381 | |
| GSE23400 | SHOX2 | 6474 | 210134_x_at | 0.0069 | 0.8414 | |
| GSE26886 | SHOX2 | 6474 | 210134_x_at | 0.2448 | 0.0254 | |
| GSE29001 | SHOX2 | 6474 | 210135_s_at | 1.7338 | 0.0001 | |
| GSE38129 | SHOX2 | 6474 | 208443_x_at | 0.7795 | 0.0001 | |
| GSE45670 | SHOX2 | 6474 | 210134_x_at | 0.1617 | 0.1332 | |
| GSE53622 | SHOX2 | 6474 | 924 | 1.0500 | 0.0000 | |
| GSE53624 | SHOX2 | 6474 | 924 | -0.1265 | 0.4125 | |
| GSE63941 | SHOX2 | 6474 | 208443_x_at | 1.5239 | 0.1044 | |
| GSE77861 | SHOX2 | 6474 | 210134_x_at | 0.0466 | 0.6317 | |
| GSE97050 | SHOX2 | 6474 | A_33_P3221859 | 0.7855 | 0.1148 | |
| SRP007169 | SHOX2 | 6474 | RNAseq | 4.9102 | 0.0009 | |
| SRP064894 | SHOX2 | 6474 | RNAseq | 6.2167 | 0.0000 | |
| SRP133303 | SHOX2 | 6474 | RNAseq | 3.8025 | 0.0000 | |
| SRP159526 | SHOX2 | 6474 | RNAseq | 4.5612 | 0.0000 | |
| SRP219564 | SHOX2 | 6474 | RNAseq | 4.6709 | 0.0000 | |
| TCGA | SHOX2 | 6474 | RNAseq | 2.0359 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by SHOX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHOX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHOX2 | 6474 | 22 | 0 | 8 | |
| GSE20123 | SHOX2 | 6474 | 22 | 0 | 8 | |
| GSE43470 | SHOX2 | 6474 | 23 | 0 | 20 | |
| GSE46452 | SHOX2 | 6474 | 18 | 2 | 39 | |
| GSE47630 | SHOX2 | 6474 | 18 | 4 | 18 | |
| GSE54993 | SHOX2 | 6474 | 1 | 11 | 58 | |
| GSE54994 | SHOX2 | 6474 | 38 | 1 | 14 | |
| GSE60625 | SHOX2 | 6474 | 0 | 6 | 5 | |
| GSE74703 | SHOX2 | 6474 | 20 | 0 | 16 | |
| GSE74704 | SHOX2 | 6474 | 14 | 0 | 6 | |
| TCGA | SHOX2 | 6474 | 75 | 1 | 20 |
Total number of gains: 251; Total number of losses: 25; Total Number of normals: 212.
Somatic mutations of SHOX2:
Generating mutation plots.
Highly correlated genes for SHOX2:
Showing top 20/206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHOX2 | CCDC57 | 0.730424 | 3 | 0 | 3 |
| SHOX2 | SLC35G1 | 0.723038 | 3 | 0 | 3 |
| SHOX2 | SALL4 | 0.705643 | 4 | 0 | 4 |
| SHOX2 | BTBD17 | 0.700152 | 3 | 0 | 3 |
| SHOX2 | PTK2B | 0.696666 | 3 | 0 | 3 |
| SHOX2 | NPM2 | 0.694325 | 4 | 0 | 4 |
| SHOX2 | ODF3L1 | 0.692956 | 3 | 0 | 3 |
| SHOX2 | LENG1 | 0.681916 | 3 | 0 | 3 |
| SHOX2 | CCDC142 | 0.681635 | 3 | 0 | 3 |
| SHOX2 | MOGAT3 | 0.667959 | 4 | 0 | 3 |
| SHOX2 | PHOSPHO1 | 0.666894 | 5 | 0 | 4 |
| SHOX2 | KCNA6 | 0.660288 | 3 | 0 | 3 |
| SHOX2 | SLCO1A2 | 0.6565 | 3 | 0 | 3 |
| SHOX2 | TERT | 0.654825 | 3 | 0 | 3 |
| SHOX2 | ADRA1A | 0.652439 | 3 | 0 | 3 |
| SHOX2 | CLTCL1 | 0.649374 | 4 | 0 | 4 |
| SHOX2 | PHF21B | 0.648765 | 3 | 0 | 3 |
| SHOX2 | LRRC10 | 0.647882 | 3 | 0 | 3 |
| SHOX2 | CDH4 | 0.646962 | 4 | 0 | 3 |
| SHOX2 | NLRP5 | 0.646376 | 3 | 0 | 3 |
For details and further investigation, click here
