| Full name: ubiquitin conjugating enzyme E2 K | Alias Symbol: HYPG|UBC1 | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 3093 | HGNC ID: HGNC:4914 | Ensembl Gene: ENSG00000078140 | OMIM ID: 602846 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBE2K:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE2K | 3093 | 225179_at | 0.1059 | 0.7917 | |
| GSE20347 | UBE2K | 3093 | 202347_s_at | -0.5396 | 0.0000 | |
| GSE23400 | UBE2K | 3093 | 202347_s_at | -0.1407 | 0.1785 | |
| GSE26886 | UBE2K | 3093 | 202347_s_at | -0.6221 | 0.0007 | |
| GSE29001 | UBE2K | 3093 | 202347_s_at | -0.1422 | 0.6944 | |
| GSE38129 | UBE2K | 3093 | 202347_s_at | -0.2061 | 0.2184 | |
| GSE45670 | UBE2K | 3093 | 202347_s_at | -0.0429 | 0.7865 | |
| GSE53622 | UBE2K | 3093 | 76279 | -0.2941 | 0.0000 | |
| GSE53624 | UBE2K | 3093 | 76279 | -0.1952 | 0.0002 | |
| GSE63941 | UBE2K | 3093 | 202347_s_at | 0.0676 | 0.8700 | |
| GSE77861 | UBE2K | 3093 | 202347_s_at | -0.2587 | 0.1472 | |
| GSE97050 | UBE2K | 3093 | A_24_P286013 | -0.4952 | 0.1417 | |
| SRP007169 | UBE2K | 3093 | RNAseq | 0.1546 | 0.7413 | |
| SRP008496 | UBE2K | 3093 | RNAseq | 0.1926 | 0.4328 | |
| SRP064894 | UBE2K | 3093 | RNAseq | -0.3302 | 0.0249 | |
| SRP133303 | UBE2K | 3093 | RNAseq | -0.1411 | 0.3566 | |
| SRP159526 | UBE2K | 3093 | RNAseq | -0.5421 | 0.0013 | |
| SRP193095 | UBE2K | 3093 | RNAseq | -0.5711 | 0.0000 | |
| SRP219564 | UBE2K | 3093 | RNAseq | -0.1940 | 0.5737 | |
| TCGA | UBE2K | 3093 | RNAseq | -0.0508 | 0.2365 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBE2K expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE2K:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE2K | 3093 | 0 | 16 | 14 | |
| GSE20123 | UBE2K | 3093 | 0 | 16 | 14 | |
| GSE43470 | UBE2K | 3093 | 0 | 15 | 28 | |
| GSE46452 | UBE2K | 3093 | 1 | 36 | 22 | |
| GSE47630 | UBE2K | 3093 | 1 | 19 | 20 | |
| GSE54993 | UBE2K | 3093 | 8 | 0 | 62 | |
| GSE54994 | UBE2K | 3093 | 3 | 10 | 40 | |
| GSE60625 | UBE2K | 3093 | 0 | 0 | 11 | |
| GSE74703 | UBE2K | 3093 | 0 | 12 | 24 | |
| GSE74704 | UBE2K | 3093 | 0 | 9 | 11 | |
| TCGA | UBE2K | 3093 | 10 | 45 | 41 |
Total number of gains: 23; Total number of losses: 178; Total Number of normals: 287.
Somatic mutations of UBE2K:
Generating mutation plots.
Highly correlated genes for UBE2K:
Showing top 20/719 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE2K | TBC1D20 | 0.736021 | 3 | 0 | 3 |
| UBE2K | ANKHD1 | 0.704654 | 3 | 0 | 3 |
| UBE2K | MANEA | 0.691551 | 3 | 0 | 3 |
| UBE2K | CCNYL1 | 0.689271 | 3 | 0 | 3 |
| UBE2K | RBMS1 | 0.685079 | 3 | 0 | 3 |
| UBE2K | TNIP1 | 0.682223 | 5 | 0 | 5 |
| UBE2K | COMMD8 | 0.656897 | 11 | 0 | 9 |
| UBE2K | ABLIM2 | 0.649921 | 4 | 0 | 4 |
| UBE2K | PPP2R5E | 0.647158 | 5 | 0 | 5 |
| UBE2K | RNF170 | 0.643576 | 8 | 0 | 6 |
| UBE2K | MPP6 | 0.642971 | 3 | 0 | 3 |
| UBE2K | HSD17B12 | 0.641283 | 4 | 0 | 4 |
| UBE2K | VTI1B | 0.640461 | 5 | 0 | 4 |
| UBE2K | HSDL2 | 0.640367 | 5 | 0 | 4 |
| UBE2K | SPNS2 | 0.637789 | 3 | 0 | 3 |
| UBE2K | WWP1 | 0.636036 | 4 | 0 | 4 |
| UBE2K | ESYT2 | 0.634516 | 4 | 0 | 3 |
| UBE2K | SECISBP2L | 0.634306 | 6 | 0 | 4 |
| UBE2K | PDLIM2 | 0.63409 | 6 | 0 | 4 |
| UBE2K | CLK1 | 0.632993 | 4 | 0 | 3 |
For details and further investigation, click here
