RANGAP1

 

Full name: Ran GTPase activating protein 1 Alias Symbol: Fug1|KIAA1835
Type: protein-coding gene Cytoband: 22q13.2
Entrez ID: 5905 HGNC ID: HGNC:9854 Ensembl Gene: ENSG00000100401 OMIM ID: 602362
Drug and gene relationship at DGIdb

 

Expression of RANGAP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RANGAP1 5905 1553535_a_at 0.1358 0.8390
GSE20347 RANGAP1 5905 212127_at 0.1636 0.1740
GSE23400 RANGAP1 5905 212127_at 0.3719 0.0000
GSE26886 RANGAP1 5905 212127_at 0.0425 0.8435
GSE29001 RANGAP1 5905 212127_at 0.2450 0.4951
GSE38129 RANGAP1 5905 212127_at 0.3998 0.0028
GSE45670 RANGAP1 5905 212127_at 0.4539 0.0030
GSE53622 RANGAP1 5905 21819 0.1487 0.0050
GSE53624 RANGAP1 5905 21819 0.2833 0.0000
GSE63941 RANGAP1 5905 1553535_a_at 1.5370 0.0037
GSE77861 RANGAP1 5905 212127_at 0.1623 0.4700
GSE97050 RANGAP1 5905 A_33_P3263307 0.0285 0.9179
SRP007169 RANGAP1 5905 RNAseq 1.0948 0.0280
SRP008496 RANGAP1 5905 RNAseq 0.9358 0.0094
SRP064894 RANGAP1 5905 RNAseq 0.8153 0.0010
SRP133303 RANGAP1 5905 RNAseq 0.2259 0.1595
SRP159526 RANGAP1 5905 RNAseq 0.6066 0.0686
SRP193095 RANGAP1 5905 RNAseq 0.3857 0.0096
SRP219564 RANGAP1 5905 RNAseq 0.4167 0.3413
TCGA RANGAP1 5905 RNAseq 0.2338 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by RANGAP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RANGAP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RANGAP1 5905 6 5 19
GSE20123 RANGAP1 5905 6 4 20
GSE43470 RANGAP1 5905 5 6 32
GSE46452 RANGAP1 5905 31 2 26
GSE47630 RANGAP1 5905 9 4 27
GSE54993 RANGAP1 5905 3 6 61
GSE54994 RANGAP1 5905 11 8 34
GSE60625 RANGAP1 5905 5 0 6
GSE74703 RANGAP1 5905 5 4 27
GSE74704 RANGAP1 5905 3 2 15
TCGA RANGAP1 5905 26 14 56

Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.  

 

Somatic mutations of RANGAP1:

 

Generating mutation plots.

 

Highly correlated genes for RANGAP1:

 

Showing top 20/337 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RANGAP1PKP30.745048303
RANGAP1RARG0.697772303
RANGAP1TMPO-AS10.697559303
RANGAP1USF20.676357303
RANGAP1KRT800.674785303
RANGAP1SLC9A3R10.673197404
RANGAP1DSP0.661492403
RANGAP1UBL7-AS10.654186404
RANGAP1CDH10.652052504
RANGAP1FAM160A10.641298303
RANGAP1ST8SIA30.640237303
RANGAP1MTFP10.637435504
RANGAP1BCR0.633484403
RANGAP1AAGAB0.63037403
RANGAP1TMPRSS40.627745505
RANGAP1ARFGAP10.619632705
RANGAP1FGFBP10.611216404
RANGAP1ATIC0.609017303
RANGAP1SDC10.608574705
RANGAP1INTS50.605339806

For details and further investigation, click here