| Full name: retinol dehydrogenase 5 | Alias Symbol: HSD17B9|SDR9C5 | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 5959 | HGNC ID: HGNC:9940 | Ensembl Gene: ENSG00000135437 | OMIM ID: 601617 |
| Drug and gene relationship at DGIdb | |||
Expression of RDH5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RDH5 | 5959 | 236291_at | -0.2591 | 0.4843 | |
| GSE26886 | RDH5 | 5959 | 236291_at | -1.0717 | 0.0000 | |
| GSE45670 | RDH5 | 5959 | 236291_at | -0.0559 | 0.7704 | |
| GSE53622 | RDH5 | 5959 | 25954 | -0.7412 | 0.0000 | |
| GSE53624 | RDH5 | 5959 | 25954 | -0.8852 | 0.0000 | |
| GSE63941 | RDH5 | 5959 | 236291_at | -0.0844 | 0.6206 | |
| GSE77861 | RDH5 | 5959 | 236291_at | -0.1175 | 0.1596 | |
| GSE97050 | RDH5 | 5959 | A_24_P218814 | -0.4367 | 0.2458 | |
| SRP064894 | RDH5 | 5959 | RNAseq | -0.8211 | 0.0050 | |
| SRP133303 | RDH5 | 5959 | RNAseq | -1.0269 | 0.0001 | |
| SRP159526 | RDH5 | 5959 | RNAseq | -0.7905 | 0.1242 | |
| SRP193095 | RDH5 | 5959 | RNAseq | -0.8991 | 0.0000 | |
| SRP219564 | RDH5 | 5959 | RNAseq | -0.7503 | 0.2959 | |
| TCGA | RDH5 | 5959 | RNAseq | -1.2029 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by RDH5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RDH5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RDH5 | 5959 | 6 | 1 | 23 | |
| GSE20123 | RDH5 | 5959 | 6 | 1 | 23 | |
| GSE43470 | RDH5 | 5959 | 4 | 0 | 39 | |
| GSE46452 | RDH5 | 5959 | 8 | 1 | 50 | |
| GSE47630 | RDH5 | 5959 | 10 | 2 | 28 | |
| GSE54993 | RDH5 | 5959 | 0 | 5 | 65 | |
| GSE54994 | RDH5 | 5959 | 4 | 1 | 48 | |
| GSE60625 | RDH5 | 5959 | 0 | 0 | 11 | |
| GSE74703 | RDH5 | 5959 | 4 | 0 | 32 | |
| GSE74704 | RDH5 | 5959 | 4 | 1 | 15 | |
| TCGA | RDH5 | 5959 | 15 | 10 | 71 |
Total number of gains: 61; Total number of losses: 22; Total Number of normals: 405.
Somatic mutations of RDH5:
Generating mutation plots.
Highly correlated genes for RDH5:
Showing top 20/324 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RDH5 | ZFP36 | 0.790364 | 3 | 0 | 3 |
| RDH5 | ADCYAP1R1 | 0.727516 | 3 | 0 | 3 |
| RDH5 | INPP5A | 0.69782 | 3 | 0 | 3 |
| RDH5 | EXOC1 | 0.692853 | 3 | 0 | 3 |
| RDH5 | PYGM | 0.690873 | 3 | 0 | 3 |
| RDH5 | CADM2 | 0.675896 | 3 | 0 | 3 |
| RDH5 | MPZL3 | 0.671159 | 3 | 0 | 3 |
| RDH5 | ACACB | 0.669624 | 5 | 0 | 5 |
| RDH5 | SHROOM3 | 0.667085 | 5 | 0 | 5 |
| RDH5 | PEA15 | 0.662086 | 5 | 0 | 5 |
| RDH5 | CYP21A2 | 0.659221 | 3 | 0 | 3 |
| RDH5 | ADCY5 | 0.657517 | 4 | 0 | 4 |
| RDH5 | ARHGAP10 | 0.656988 | 7 | 0 | 6 |
| RDH5 | CSRNP1 | 0.655863 | 5 | 0 | 4 |
| RDH5 | RUSC2 | 0.654644 | 6 | 0 | 5 |
| RDH5 | ZNF582 | 0.653439 | 4 | 0 | 4 |
| RDH5 | MYZAP | 0.653293 | 3 | 0 | 3 |
| RDH5 | SCN7A | 0.650257 | 3 | 0 | 3 |
| RDH5 | SH3BGR | 0.649182 | 3 | 0 | 3 |
| RDH5 | RBFOX3 | 0.649155 | 3 | 0 | 3 |
For details and further investigation, click here
