| Full name: succinate dehydrogenase complex flavoprotein subunit A | Alias Symbol: FP|SDHF | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 6389 | HGNC ID: HGNC:10680 | Ensembl Gene: ENSG00000073578 | OMIM ID: 600857 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SDHA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDHA | 6389 | 201093_x_at | 0.2048 | 0.3826 | |
| GSE20347 | SDHA | 6389 | 201093_x_at | 0.2981 | 0.0119 | |
| GSE23400 | SDHA | 6389 | 201093_x_at | 0.0439 | 0.4938 | |
| GSE26886 | SDHA | 6389 | 201093_x_at | 0.1291 | 0.5221 | |
| GSE29001 | SDHA | 6389 | 201093_x_at | -0.0123 | 0.9593 | |
| GSE38129 | SDHA | 6389 | 201093_x_at | 0.1189 | 0.2530 | |
| GSE45670 | SDHA | 6389 | 201093_x_at | -0.1368 | 0.3231 | |
| GSE53622 | SDHA | 6389 | 29947 | -0.2719 | 0.0000 | |
| GSE53624 | SDHA | 6389 | 29947 | 0.1869 | 0.0005 | |
| GSE63941 | SDHA | 6389 | 201093_x_at | 0.6694 | 0.1080 | |
| GSE77861 | SDHA | 6389 | 201093_x_at | 0.5891 | 0.0322 | |
| GSE97050 | SDHA | 6389 | A_23_P250035 | 0.0512 | 0.8017 | |
| SRP007169 | SDHA | 6389 | RNAseq | -0.4429 | 0.2902 | |
| SRP008496 | SDHA | 6389 | RNAseq | -0.4060 | 0.1887 | |
| SRP064894 | SDHA | 6389 | RNAseq | -0.3373 | 0.0327 | |
| SRP133303 | SDHA | 6389 | RNAseq | 0.1044 | 0.5354 | |
| SRP159526 | SDHA | 6389 | RNAseq | 0.2959 | 0.4060 | |
| SRP193095 | SDHA | 6389 | RNAseq | -0.3708 | 0.0117 | |
| SRP219564 | SDHA | 6389 | RNAseq | -0.1974 | 0.6809 | |
| TCGA | SDHA | 6389 | RNAseq | -0.1372 | 0.0095 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SDHA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SDHA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDHA | 6389 | 12 | 2 | 16 | |
| GSE20123 | SDHA | 6389 | 12 | 1 | 17 | |
| GSE43470 | SDHA | 6389 | 16 | 0 | 27 | |
| GSE46452 | SDHA | 6389 | 6 | 22 | 31 | |
| GSE47630 | SDHA | 6389 | 11 | 9 | 20 | |
| GSE54993 | SDHA | 6389 | 5 | 6 | 59 | |
| GSE54994 | SDHA | 6389 | 29 | 1 | 23 | |
| GSE60625 | SDHA | 6389 | 0 | 0 | 11 | |
| GSE74703 | SDHA | 6389 | 13 | 0 | 23 | |
| GSE74704 | SDHA | 6389 | 11 | 0 | 9 | |
| TCGA | SDHA | 6389 | 60 | 4 | 32 |
Total number of gains: 175; Total number of losses: 45; Total Number of normals: 268.
Somatic mutations of SDHA:
Generating mutation plots.
Highly correlated genes for SDHA:
Showing top 20/78 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDHA | MED10 | 0.680546 | 4 | 0 | 3 |
| SDHA | ITM2C | 0.66179 | 3 | 0 | 3 |
| SDHA | CCDC127 | 0.655004 | 8 | 0 | 6 |
| SDHA | INSR | 0.651271 | 4 | 0 | 3 |
| SDHA | MAFK | 0.646561 | 3 | 0 | 3 |
| SDHA | EPPK1 | 0.643535 | 3 | 0 | 3 |
| SDHA | HOXC9 | 0.641894 | 3 | 0 | 3 |
| SDHA | E2F1 | 0.639514 | 4 | 0 | 4 |
| SDHA | IQCK | 0.624228 | 3 | 0 | 3 |
| SDHA | NCBP2 | 0.616836 | 3 | 0 | 3 |
| SDHA | SLC12A7 | 0.616333 | 3 | 0 | 3 |
| SDHA | SEMA4C | 0.61278 | 4 | 0 | 4 |
| SDHA | MYNN | 0.612385 | 3 | 0 | 3 |
| SDHA | CCNB1IP1 | 0.609203 | 3 | 0 | 3 |
| SDHA | IFT140 | 0.609191 | 3 | 0 | 3 |
| SDHA | LAMA3 | 0.607147 | 3 | 0 | 3 |
| SDHA | RNF139-AS1 | 0.604565 | 3 | 0 | 3 |
| SDHA | ENO2 | 0.597851 | 3 | 0 | 3 |
| SDHA | TIMELESS | 0.589426 | 3 | 0 | 3 |
| SDHA | NDUFS6 | 0.588206 | 8 | 0 | 5 |
For details and further investigation, click here
