| Full name: splicing factor 3b subunit 3 | Alias Symbol: SAP130|SF3b130|RSE1|KIAA0017 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 23450 | HGNC ID: HGNC:10770 | Ensembl Gene: ENSG00000189091 | OMIM ID: 605592 |
| Drug and gene relationship at DGIdb | |||
Expression of SF3B3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SF3B3 | 23450 | 200687_s_at | 0.1164 | 0.8927 | |
| GSE20347 | SF3B3 | 23450 | 200687_s_at | -0.6012 | 0.0001 | |
| GSE23400 | SF3B3 | 23450 | 200687_s_at | -0.1876 | 0.0296 | |
| GSE26886 | SF3B3 | 23450 | 200687_s_at | -0.8175 | 0.0002 | |
| GSE29001 | SF3B3 | 23450 | 200687_s_at | -0.4844 | 0.0728 | |
| GSE38129 | SF3B3 | 23450 | 200687_s_at | -0.2697 | 0.1307 | |
| GSE45670 | SF3B3 | 23450 | 200687_s_at | -0.3072 | 0.0422 | |
| GSE53622 | SF3B3 | 23450 | 36306 | 0.3966 | 0.0000 | |
| GSE53624 | SF3B3 | 23450 | 35911 | -0.4104 | 0.0000 | |
| GSE63941 | SF3B3 | 23450 | 200687_s_at | 1.0302 | 0.0224 | |
| GSE77861 | SF3B3 | 23450 | 200687_s_at | -0.4346 | 0.0278 | |
| GSE97050 | SF3B3 | 23450 | A_32_P173298 | 0.4214 | 0.2873 | |
| SRP007169 | SF3B3 | 23450 | RNAseq | -0.5625 | 0.1243 | |
| SRP008496 | SF3B3 | 23450 | RNAseq | -0.5554 | 0.0083 | |
| SRP064894 | SF3B3 | 23450 | RNAseq | -0.3517 | 0.0056 | |
| SRP133303 | SF3B3 | 23450 | RNAseq | 0.2553 | 0.1664 | |
| SRP159526 | SF3B3 | 23450 | RNAseq | 0.4842 | 0.1679 | |
| SRP193095 | SF3B3 | 23450 | RNAseq | 0.1922 | 0.1174 | |
| SRP219564 | SF3B3 | 23450 | RNAseq | -0.0729 | 0.8270 | |
| TCGA | SF3B3 | 23450 | RNAseq | 0.1974 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SF3B3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SF3B3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SF3B3 | 23450 | 6 | 1 | 23 | |
| GSE20123 | SF3B3 | 23450 | 6 | 1 | 23 | |
| GSE43470 | SF3B3 | 23450 | 2 | 8 | 33 | |
| GSE46452 | SF3B3 | 23450 | 38 | 1 | 20 | |
| GSE47630 | SF3B3 | 23450 | 11 | 8 | 21 | |
| GSE54993 | SF3B3 | 23450 | 2 | 4 | 64 | |
| GSE54994 | SF3B3 | 23450 | 8 | 10 | 35 | |
| GSE60625 | SF3B3 | 23450 | 4 | 0 | 7 | |
| GSE74703 | SF3B3 | 23450 | 2 | 5 | 29 | |
| GSE74704 | SF3B3 | 23450 | 3 | 0 | 17 | |
| TCGA | SF3B3 | 23450 | 27 | 12 | 57 |
Total number of gains: 109; Total number of losses: 50; Total Number of normals: 329.
Somatic mutations of SF3B3:
Generating mutation plots.
Highly correlated genes for SF3B3:
Showing top 20/714 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SF3B3 | ZNRF1 | 0.762052 | 4 | 0 | 4 |
| SF3B3 | GRHL3 | 0.695797 | 4 | 0 | 4 |
| SF3B3 | CLEC16A | 0.680899 | 4 | 0 | 3 |
| SF3B3 | POLR2L | 0.680612 | 4 | 0 | 4 |
| SF3B3 | RCC1 | 0.676391 | 4 | 0 | 3 |
| SF3B3 | ARHGEF5 | 0.676302 | 4 | 0 | 4 |
| SF3B3 | A2ML1 | 0.674192 | 3 | 0 | 3 |
| SF3B3 | CNOT1 | 0.673056 | 10 | 0 | 9 |
| SF3B3 | NUP188 | 0.671389 | 4 | 0 | 3 |
| SF3B3 | ATP11B | 0.671296 | 4 | 0 | 3 |
| SF3B3 | GRHPR | 0.670983 | 3 | 0 | 3 |
| SF3B3 | TPRG1 | 0.670831 | 5 | 0 | 5 |
| SF3B3 | RBAK | 0.670092 | 3 | 0 | 3 |
| SF3B3 | NDUFA3 | 0.66986 | 4 | 0 | 4 |
| SF3B3 | SRD5A1 | 0.668325 | 5 | 0 | 4 |
| SF3B3 | CDK10 | 0.666287 | 3 | 0 | 3 |
| SF3B3 | SH3GL1 | 0.658721 | 9 | 0 | 7 |
| SF3B3 | GTF3C6 | 0.65619 | 3 | 0 | 3 |
| SF3B3 | JAG1 | 0.6526 | 4 | 0 | 3 |
| SF3B3 | CSK | 0.652257 | 9 | 0 | 7 |
For details and further investigation, click here
