| Full name: SMAD family member 6 | Alias Symbol: HsT17432 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 4091 | HGNC ID: HGNC:6772 | Ensembl Gene: ENSG00000137834 | OMIM ID: 602931 |
| Drug and gene relationship at DGIdb | |||
SMAD6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway |
Expression of SMAD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMAD6 | 4091 | 207069_s_at | 0.0791 | 0.9082 | |
| GSE20347 | SMAD6 | 4091 | 207069_s_at | 0.2252 | 0.1717 | |
| GSE23400 | SMAD6 | 4091 | 209887_at | -0.0324 | 0.3282 | |
| GSE26886 | SMAD6 | 4091 | 207069_s_at | 1.3737 | 0.0001 | |
| GSE29001 | SMAD6 | 4091 | 207069_s_at | 0.2216 | 0.4216 | |
| GSE38129 | SMAD6 | 4091 | 207069_s_at | -0.0993 | 0.6412 | |
| GSE45670 | SMAD6 | 4091 | 207069_s_at | -0.4726 | 0.0677 | |
| GSE53622 | SMAD6 | 4091 | 49890 | -0.4022 | 0.0031 | |
| GSE53624 | SMAD6 | 4091 | 49890 | 0.0881 | 0.5151 | |
| GSE63941 | SMAD6 | 4091 | 207069_s_at | -1.5816 | 0.0596 | |
| GSE77861 | SMAD6 | 4091 | 209886_s_at | -0.0816 | 0.6238 | |
| GSE97050 | SMAD6 | 4091 | A_33_P3220470 | -0.0575 | 0.8485 | |
| SRP007169 | SMAD6 | 4091 | RNAseq | -0.5920 | 0.3400 | |
| SRP064894 | SMAD6 | 4091 | RNAseq | 0.0270 | 0.9243 | |
| SRP133303 | SMAD6 | 4091 | RNAseq | -0.1714 | 0.5334 | |
| SRP159526 | SMAD6 | 4091 | RNAseq | 0.6152 | 0.2542 | |
| SRP193095 | SMAD6 | 4091 | RNAseq | 0.5748 | 0.1186 | |
| SRP219564 | SMAD6 | 4091 | RNAseq | 0.4147 | 0.5276 | |
| TCGA | SMAD6 | 4091 | RNAseq | -0.4790 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SMAD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMAD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMAD6 | 4091 | 7 | 3 | 20 | |
| GSE20123 | SMAD6 | 4091 | 7 | 3 | 20 | |
| GSE43470 | SMAD6 | 4091 | 4 | 6 | 33 | |
| GSE46452 | SMAD6 | 4091 | 3 | 7 | 49 | |
| GSE47630 | SMAD6 | 4091 | 8 | 10 | 22 | |
| GSE54993 | SMAD6 | 4091 | 5 | 6 | 59 | |
| GSE54994 | SMAD6 | 4091 | 6 | 7 | 40 | |
| GSE60625 | SMAD6 | 4091 | 4 | 0 | 7 | |
| GSE74703 | SMAD6 | 4091 | 4 | 3 | 29 | |
| GSE74704 | SMAD6 | 4091 | 3 | 3 | 14 | |
| TCGA | SMAD6 | 4091 | 10 | 15 | 71 |
Total number of gains: 61; Total number of losses: 63; Total Number of normals: 364.
Somatic mutations of SMAD6:
Generating mutation plots.
Highly correlated genes for SMAD6:
Showing top 20/196 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMAD6 | TEAD2 | 0.735553 | 3 | 0 | 3 |
| SMAD6 | ALDH1L2 | 0.655131 | 3 | 0 | 3 |
| SMAD6 | MAST2 | 0.643486 | 4 | 0 | 3 |
| SMAD6 | GRAMD1A | 0.641098 | 3 | 0 | 3 |
| SMAD6 | PIGX | 0.640528 | 3 | 0 | 3 |
| SMAD6 | TET1 | 0.635968 | 3 | 0 | 3 |
| SMAD6 | FGF3 | 0.633652 | 3 | 0 | 3 |
| SMAD6 | BEGAIN | 0.620781 | 3 | 0 | 3 |
| SMAD6 | GPX8 | 0.619337 | 4 | 0 | 3 |
| SMAD6 | IDS | 0.616636 | 4 | 0 | 3 |
| SMAD6 | MACF1 | 0.614847 | 3 | 0 | 3 |
| SMAD6 | C19orf54 | 0.613117 | 3 | 0 | 3 |
| SMAD6 | NFIL3 | 0.610465 | 3 | 0 | 3 |
| SMAD6 | GLIS2 | 0.607918 | 5 | 0 | 4 |
| SMAD6 | RPAP1 | 0.605045 | 4 | 0 | 3 |
| SMAD6 | COL6A1 | 0.604892 | 6 | 0 | 5 |
| SMAD6 | TARSL2 | 0.60363 | 4 | 0 | 4 |
| SMAD6 | BAD | 0.601015 | 3 | 0 | 3 |
| SMAD6 | NES | 0.599105 | 7 | 0 | 6 |
| SMAD6 | SAMD11 | 0.597682 | 3 | 0 | 3 |
For details and further investigation, click here
