| Full name: SMG7 nonsense mediated mRNA decay factor | Alias Symbol: KIAA0250|EST1C|SGA56M|SMG-7 | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 9887 | HGNC ID: HGNC:16792 | Ensembl Gene: ENSG00000116698 | OMIM ID: 610964 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SMG7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMG7 | 9887 | 201794_s_at | 0.9040 | 0.0423 | |
| GSE20347 | SMG7 | 9887 | 201794_s_at | 0.6768 | 0.0002 | |
| GSE23400 | SMG7 | 9887 | 201794_s_at | 0.6307 | 0.0000 | |
| GSE26886 | SMG7 | 9887 | 201794_s_at | -0.7035 | 0.0138 | |
| GSE29001 | SMG7 | 9887 | 201794_s_at | 0.5508 | 0.1523 | |
| GSE38129 | SMG7 | 9887 | 201794_s_at | 0.6153 | 0.0001 | |
| GSE45670 | SMG7 | 9887 | 201794_s_at | 0.4139 | 0.0011 | |
| GSE53622 | SMG7 | 9887 | 41075 | 0.5048 | 0.0000 | |
| GSE53624 | SMG7 | 9887 | 41075 | 0.6518 | 0.0000 | |
| GSE63941 | SMG7 | 9887 | 201794_s_at | 0.2059 | 0.5910 | |
| GSE77861 | SMG7 | 9887 | 201794_s_at | 0.7625 | 0.0035 | |
| GSE97050 | SMG7 | 9887 | A_33_P3356035 | 0.0835 | 0.7592 | |
| SRP007169 | SMG7 | 9887 | RNAseq | 0.1522 | 0.7230 | |
| SRP008496 | SMG7 | 9887 | RNAseq | 0.3187 | 0.1523 | |
| SRP064894 | SMG7 | 9887 | RNAseq | 0.1672 | 0.2556 | |
| SRP133303 | SMG7 | 9887 | RNAseq | 0.5134 | 0.0002 | |
| SRP159526 | SMG7 | 9887 | RNAseq | 0.6890 | 0.0053 | |
| SRP193095 | SMG7 | 9887 | RNAseq | 0.1263 | 0.2287 | |
| SRP219564 | SMG7 | 9887 | RNAseq | 0.5210 | 0.1398 | |
| TCGA | SMG7 | 9887 | RNAseq | 0.1117 | 0.0086 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SMG7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMG7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMG7 | 9887 | 12 | 0 | 18 | |
| GSE20123 | SMG7 | 9887 | 12 | 0 | 18 | |
| GSE43470 | SMG7 | 9887 | 7 | 1 | 35 | |
| GSE46452 | SMG7 | 9887 | 3 | 1 | 55 | |
| GSE47630 | SMG7 | 9887 | 14 | 0 | 26 | |
| GSE54993 | SMG7 | 9887 | 0 | 6 | 64 | |
| GSE54994 | SMG7 | 9887 | 15 | 0 | 38 | |
| GSE60625 | SMG7 | 9887 | 0 | 0 | 11 | |
| GSE74703 | SMG7 | 9887 | 7 | 1 | 28 | |
| GSE74704 | SMG7 | 9887 | 5 | 0 | 15 | |
| TCGA | SMG7 | 9887 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of SMG7:
Generating mutation plots.
Highly correlated genes for SMG7:
Showing top 20/211 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMG7 | HOXC9 | 0.795411 | 4 | 0 | 4 |
| SMG7 | CC2D1B | 0.752196 | 3 | 0 | 3 |
| SMG7 | TOR3A | 0.696517 | 8 | 0 | 8 |
| SMG7 | C5orf30 | 0.682743 | 3 | 0 | 3 |
| SMG7 | ABT1 | 0.681529 | 4 | 0 | 4 |
| SMG7 | YBX1 | 0.662998 | 4 | 0 | 4 |
| SMG7 | BAX | 0.656116 | 5 | 0 | 3 |
| SMG7 | DCPS | 0.65265 | 4 | 0 | 3 |
| SMG7 | TAF5L | 0.651478 | 7 | 0 | 4 |
| SMG7 | FOXM1 | 0.646165 | 8 | 0 | 7 |
| SMG7 | CHEK2 | 0.642306 | 8 | 0 | 7 |
| SMG7 | TAF5 | 0.641542 | 8 | 0 | 7 |
| SMG7 | ECT2 | 0.641176 | 8 | 0 | 6 |
| SMG7 | CCDC137 | 0.638607 | 3 | 0 | 3 |
| SMG7 | NLRC5 | 0.636972 | 3 | 0 | 3 |
| SMG7 | FLAD1 | 0.632689 | 9 | 0 | 7 |
| SMG7 | EIF3B | 0.63087 | 9 | 0 | 9 |
| SMG7 | TMEM68 | 0.630449 | 3 | 0 | 3 |
| SMG7 | SMG5 | 0.629932 | 10 | 0 | 9 |
| SMG7 | APMAP | 0.625803 | 8 | 0 | 8 |
For details and further investigation, click here
