| Full name: suppressor of cytokine signaling 1 | Alias Symbol: SOCS-1|SSI-1|JAB|TIP3|Cish1 | ||
| Type: protein-coding gene | Cytoband: 16p13.13 | ||
| Entrez ID: 8651 | HGNC ID: HGNC:19383 | Ensembl Gene: ENSG00000185338 | OMIM ID: 603597 |
| Drug and gene relationship at DGIdb | |||
SOCS1 involved pathways:
Expression of SOCS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOCS1 | 8651 | 210001_s_at | 0.6743 | 0.2948 | |
| GSE20347 | SOCS1 | 8651 | 213337_s_at | 0.0700 | 0.3445 | |
| GSE23400 | SOCS1 | 8651 | 210001_s_at | 0.9591 | 0.0000 | |
| GSE26886 | SOCS1 | 8651 | 213337_s_at | 0.2580 | 0.0384 | |
| GSE29001 | SOCS1 | 8651 | 210001_s_at | 2.3020 | 0.0000 | |
| GSE38129 | SOCS1 | 8651 | 210001_s_at | 1.3259 | 0.0000 | |
| GSE45670 | SOCS1 | 8651 | 210001_s_at | 1.1680 | 0.0013 | |
| GSE53622 | SOCS1 | 8651 | 138001 | 1.4965 | 0.0000 | |
| GSE53624 | SOCS1 | 8651 | 138001 | 1.4829 | 0.0000 | |
| GSE63941 | SOCS1 | 8651 | 213337_s_at | 0.1135 | 0.4316 | |
| GSE77861 | SOCS1 | 8651 | 210001_s_at | 0.6597 | 0.0013 | |
| GSE97050 | SOCS1 | 8651 | A_23_P420196 | 0.6930 | 0.1241 | |
| SRP007169 | SOCS1 | 8651 | RNAseq | 3.1879 | 0.0001 | |
| SRP064894 | SOCS1 | 8651 | RNAseq | 0.4940 | 0.2136 | |
| SRP133303 | SOCS1 | 8651 | RNAseq | 1.2423 | 0.0000 | |
| SRP159526 | SOCS1 | 8651 | RNAseq | 0.9265 | 0.0124 | |
| SRP219564 | SOCS1 | 8651 | RNAseq | 0.6726 | 0.1277 | |
| TCGA | SOCS1 | 8651 | RNAseq | 0.4061 | 0.0023 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by SOCS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOCS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOCS1 | 8651 | 5 | 4 | 21 | |
| GSE20123 | SOCS1 | 8651 | 5 | 3 | 22 | |
| GSE43470 | SOCS1 | 8651 | 3 | 3 | 37 | |
| GSE46452 | SOCS1 | 8651 | 38 | 1 | 20 | |
| GSE47630 | SOCS1 | 8651 | 14 | 6 | 20 | |
| GSE54993 | SOCS1 | 8651 | 3 | 5 | 62 | |
| GSE54994 | SOCS1 | 8651 | 5 | 9 | 39 | |
| GSE60625 | SOCS1 | 8651 | 4 | 0 | 7 | |
| GSE74703 | SOCS1 | 8651 | 3 | 2 | 31 | |
| GSE74704 | SOCS1 | 8651 | 2 | 1 | 17 | |
| TCGA | SOCS1 | 8651 | 20 | 12 | 64 |
Total number of gains: 102; Total number of losses: 46; Total Number of normals: 340.
Somatic mutations of SOCS1:
Generating mutation plots.
Highly correlated genes for SOCS1:
Showing top 20/1261 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOCS1 | FEN1 | 0.733183 | 5 | 0 | 5 |
| SOCS1 | PDIA5 | 0.71905 | 3 | 0 | 3 |
| SOCS1 | PYCR2 | 0.718682 | 3 | 0 | 3 |
| SOCS1 | FUS | 0.711721 | 8 | 0 | 8 |
| SOCS1 | MARCKSL1 | 0.710526 | 10 | 0 | 9 |
| SOCS1 | DNAJB11 | 0.697742 | 5 | 0 | 5 |
| SOCS1 | LRRC8C | 0.693509 | 3 | 0 | 3 |
| SOCS1 | GNA12 | 0.692184 | 9 | 0 | 9 |
| SOCS1 | SNAP47 | 0.690133 | 3 | 0 | 3 |
| SOCS1 | FNDC3B | 0.68862 | 10 | 0 | 9 |
| SOCS1 | FCGR3A | 0.681954 | 3 | 0 | 3 |
| SOCS1 | FADS1 | 0.680267 | 3 | 0 | 3 |
| SOCS1 | MTBP | 0.679185 | 4 | 0 | 4 |
| SOCS1 | SH3PXD2B | 0.677124 | 7 | 0 | 7 |
| SOCS1 | USP41 | 0.675224 | 3 | 0 | 3 |
| SOCS1 | FMNL2 | 0.67461 | 7 | 0 | 6 |
| SOCS1 | KIF14 | 0.671936 | 8 | 0 | 7 |
| SOCS1 | IGFBP3 | 0.671417 | 8 | 0 | 8 |
| SOCS1 | LPCAT1 | 0.669095 | 10 | 0 | 9 |
| SOCS1 | LEPR | 0.668937 | 3 | 0 | 3 |
For details and further investigation, click here
