| Full name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10p12.33 | ||
| Entrez ID: 338596 | HGNC ID: HGNC:23317 | Ensembl Gene: ENSG00000148488 | OMIM ID: 610139 |
| Drug and gene relationship at DGIdb | |||
Expression of ST8SIA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | ST8SIA6 | 338596 | 36657 | -1.5337 | 0.0000 | |
| GSE53624 | ST8SIA6 | 338596 | 36657 | -2.0324 | 0.0000 | |
| GSE97050 | ST8SIA6 | 338596 | A_33_P3366758 | -0.5000 | 0.3094 | |
| SRP064894 | ST8SIA6 | 338596 | RNAseq | -1.2032 | 0.0000 | |
| SRP133303 | ST8SIA6 | 338596 | RNAseq | -0.4550 | 0.0946 | |
| SRP159526 | ST8SIA6 | 338596 | RNAseq | 0.3340 | 0.6551 | |
| SRP193095 | ST8SIA6 | 338596 | RNAseq | -0.5598 | 0.0001 | |
| SRP219564 | ST8SIA6 | 338596 | RNAseq | -1.3436 | 0.0228 | |
| TCGA | ST8SIA6 | 338596 | RNAseq | -0.5523 | 0.3483 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ST8SIA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ST8SIA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ST8SIA6 | 338596 | 3 | 8 | 19 | |
| GSE20123 | ST8SIA6 | 338596 | 3 | 7 | 20 | |
| GSE43470 | ST8SIA6 | 338596 | 3 | 4 | 36 | |
| GSE46452 | ST8SIA6 | 338596 | 1 | 14 | 44 | |
| GSE47630 | ST8SIA6 | 338596 | 5 | 15 | 20 | |
| GSE54993 | ST8SIA6 | 338596 | 10 | 0 | 60 | |
| GSE54994 | ST8SIA6 | 338596 | 4 | 9 | 40 | |
| GSE60625 | ST8SIA6 | 338596 | 0 | 0 | 11 | |
| GSE74703 | ST8SIA6 | 338596 | 2 | 3 | 31 | |
| GSE74704 | ST8SIA6 | 338596 | 0 | 6 | 14 | |
| TCGA | ST8SIA6 | 338596 | 19 | 26 | 51 |
Total number of gains: 50; Total number of losses: 92; Total Number of normals: 346.
Somatic mutations of ST8SIA6:
Generating mutation plots.
Highly correlated genes for ST8SIA6:
Showing top 20/171 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ST8SIA6 | PLEKHA7 | 0.72781 | 3 | 0 | 3 |
| ST8SIA6 | SORT1 | 0.721044 | 3 | 0 | 3 |
| ST8SIA6 | PAIP2B | 0.709148 | 3 | 0 | 3 |
| ST8SIA6 | FCER1A | 0.699278 | 3 | 0 | 3 |
| ST8SIA6 | FMO2 | 0.699123 | 3 | 0 | 3 |
| ST8SIA6 | PAQR8 | 0.697599 | 3 | 0 | 3 |
| ST8SIA6 | NCOA1 | 0.683508 | 3 | 0 | 3 |
| ST8SIA6 | N4BP3 | 0.683257 | 3 | 0 | 3 |
| ST8SIA6 | ASAH1 | 0.682354 | 3 | 0 | 3 |
| ST8SIA6 | RMND5B | 0.680499 | 3 | 0 | 3 |
| ST8SIA6 | HPGD | 0.678987 | 3 | 0 | 3 |
| ST8SIA6 | SASH1 | 0.672244 | 3 | 0 | 3 |
| ST8SIA6 | GPD1L | 0.670624 | 3 | 0 | 3 |
| ST8SIA6 | ACOX3 | 0.669496 | 3 | 0 | 3 |
| ST8SIA6 | C18orf25 | 0.666308 | 3 | 0 | 3 |
| ST8SIA6 | USP6NL | 0.665687 | 3 | 0 | 3 |
| ST8SIA6 | FCHO2 | 0.665674 | 3 | 0 | 3 |
| ST8SIA6 | ADH1B | 0.664881 | 3 | 0 | 3 |
| ST8SIA6 | CPEB3 | 0.662793 | 3 | 0 | 3 |
| ST8SIA6 | STK39 | 0.659977 | 3 | 0 | 3 |
For details and further investigation, click here
