Full name: signal transducer and activator of transcription 3	Alias Symbol: APRF
Type: protein-coding gene	Cytoband: 17q21.2
Entrez ID: 6774	HGNC ID: HGNC:11364	Ensembl Gene: ENSG00000168610	OMIM ID: 102582
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 7/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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STAT3 involved pathways:

KEGG pathway	Description	View
hsa04062	Chemokine signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04068	FoxO signaling pathway	View
hsa04550	Signaling pathways regulating pluripotency of stem cells	View
hsa04630	Jak-STAT signaling pathway	View
hsa04917	Prolactin signaling pathway	View
hsa04920	Adipocytokine signaling pathway	View
hsa04931	Insulin resistance	View
hsa04933	AGE-RAGE signaling pathway in diabetic complications	View
hsa05145	Toxoplasmosis	View
hsa05160	Hepatitis C	View
hsa05161	Hepatitis B	View
hsa05162	Measles	View
hsa05169	Epstein-Barr virus infection	View
hsa05200	Pathways in cancer	View
hsa05205	Proteoglycans in cancer	View
hsa05212	Pancreatic cancer	View
hsa05221	Acute myeloid leukemia	View
hsa05321	Inflammatory bowel disease (IBD)	View

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Expression of STAT3:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	STAT3	6774	208991_at	-0.0362	0.9513	Show
GSE20347	STAT3	6774	208991_at	-0.2203	0.3488	Show
GSE23400	STAT3	6774	208991_at	0.1075	0.1549	Show
GSE26886	STAT3	6774	208991_at	-0.7374	0.0278	Show
GSE29001	STAT3	6774	208991_at	-0.0957	0.7666	Show
GSE38129	STAT3	6774	208991_at	-0.1990	0.2169	Show
GSE45670	STAT3	6774	208991_at	0.4102	0.0021	Show
GSE53622	STAT3	6774	78123	0.1612	0.0053	Show
GSE53624	STAT3	6774	78123	-0.0882	0.1052	Show
GSE63941	STAT3	6774	208991_at	-0.7312	0.2250	Show
GSE77861	STAT3	6774	208991_at	0.3205	0.2129	Show
GSE97050	STAT3	6774	A_24_P116805	0.8806	0.1095	Show
SRP007169	STAT3	6774	RNAseq	-0.5679	0.0766	Show
SRP008496	STAT3	6774	RNAseq	-0.8810	0.0001	Show
SRP064894	STAT3	6774	RNAseq	0.1104	0.5478	Show
SRP133303	STAT3	6774	RNAseq	0.2118	0.1535	Show
SRP159526	STAT3	6774	RNAseq	0.1620	0.6249	Show
SRP193095	STAT3	6774	RNAseq	-0.0404	0.7717	Show
SRP219564	STAT3	6774	RNAseq	-0.0372	0.9068	Show
TCGA	STAT3	6774	RNAseq	0.0249	0.5594	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by STAT3 expression:

 

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Copy number change of STAT3:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	STAT3	6774	6	2	22	Show
GSE20123	STAT3	6774	6	2	22	Show
GSE43470	STAT3	6774	1	2	40	Show
GSE46452	STAT3	6774	34	0	25	Show
GSE47630	STAT3	6774	8	1	31	Show
GSE54993	STAT3	6774	3	4	63	Show
GSE54994	STAT3	6774	8	5	40	Show
GSE60625	STAT3	6774	4	0	7	Show
GSE74703	STAT3	6774	1	1	34	Show
GSE74704	STAT3	6774	4	1	15	Show
TCGA	STAT3	6774	23	6	67	Show

Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.  Download Data

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Somatic mutations of STAT3:

 

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Highly correlated genes for STAT3:

 

Showing top 20/45 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
STAT3	MCOLN2	0.625126	3	0	3
STAT3	CD14	0.621044	4	0	4
STAT3	KLK6	0.611303	4	0	3
STAT3	TRAPPC11	0.596275	3	0	3
STAT3	LPAR6	0.596101	4	0	4
STAT3	TMC8	0.58902	3	0	3
STAT3	FAM43A	0.587386	4	0	3
STAT3	HSD17B2	0.587279	3	0	3
STAT3	SLC28A3	0.585991	4	0	3
STAT3	FRMD8	0.583749	4	0	3
STAT3	IRAK2	0.580655	3	0	3
STAT3	TOP1	0.576559	4	0	3
STAT3	LPXN	0.574819	4	0	3
STAT3	SLCO2A1	0.570002	3	0	3
STAT3	S100A7	0.562701	5	0	4
STAT3	CSF2RB	0.561889	6	0	3
STAT3	CDK5RAP3	0.560981	4	0	3
STAT3	COASY	0.558416	4	0	3
STAT3	SOD2	0.556515	5	0	4
STAT3	PDZK1IP1	0.553402	6	0	4

For details and further investigation, click here