| Full name: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Alias Symbol: TIRC7|OC-116|OC116|ATP6N1C|Atp6i|a3|ATP6V0A3 | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 10312 | HGNC ID: HGNC:11647 | Ensembl Gene: ENSG00000110719 | OMIM ID: 604592 |
| Drug and gene relationship at DGIdb | |||
TCIRG1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05110 | Vibrio cholerae infection | |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | |
| hsa05152 | Tuberculosis |
Expression of TCIRG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TCIRG1 | 10312 | 204158_s_at | 0.6830 | 0.2004 | |
| GSE20347 | TCIRG1 | 10312 | 204158_s_at | 0.2699 | 0.2120 | |
| GSE23400 | TCIRG1 | 10312 | 204158_s_at | 0.3816 | 0.0002 | |
| GSE26886 | TCIRG1 | 10312 | 204158_s_at | 0.9312 | 0.0009 | |
| GSE29001 | TCIRG1 | 10312 | 204158_s_at | 0.4316 | 0.2213 | |
| GSE38129 | TCIRG1 | 10312 | 204158_s_at | 0.1364 | 0.5448 | |
| GSE45670 | TCIRG1 | 10312 | 204158_s_at | 0.4364 | 0.0059 | |
| GSE53622 | TCIRG1 | 10312 | 73656 | 0.2993 | 0.0000 | |
| GSE53624 | TCIRG1 | 10312 | 73656 | 0.2603 | 0.0000 | |
| GSE63941 | TCIRG1 | 10312 | 204158_s_at | -1.7333 | 0.0554 | |
| GSE77861 | TCIRG1 | 10312 | 204158_s_at | 0.1144 | 0.6666 | |
| GSE97050 | TCIRG1 | 10312 | A_33_P3219965 | 0.5635 | 0.1970 | |
| SRP007169 | TCIRG1 | 10312 | RNAseq | 0.8238 | 0.1621 | |
| SRP008496 | TCIRG1 | 10312 | RNAseq | 0.3508 | 0.3404 | |
| SRP064894 | TCIRG1 | 10312 | RNAseq | 1.1156 | 0.0000 | |
| SRP133303 | TCIRG1 | 10312 | RNAseq | 0.5066 | 0.0150 | |
| SRP159526 | TCIRG1 | 10312 | RNAseq | -0.2207 | 0.4888 | |
| SRP193095 | TCIRG1 | 10312 | RNAseq | 0.9275 | 0.0002 | |
| SRP219564 | TCIRG1 | 10312 | RNAseq | 0.8932 | 0.0019 | |
| TCGA | TCIRG1 | 10312 | RNAseq | -0.0098 | 0.8865 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TCIRG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TCIRG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TCIRG1 | 10312 | 10 | 3 | 17 | |
| GSE20123 | TCIRG1 | 10312 | 10 | 3 | 17 | |
| GSE43470 | TCIRG1 | 10312 | 4 | 3 | 36 | |
| GSE46452 | TCIRG1 | 10312 | 15 | 3 | 41 | |
| GSE47630 | TCIRG1 | 10312 | 10 | 5 | 25 | |
| GSE54993 | TCIRG1 | 10312 | 3 | 2 | 65 | |
| GSE54994 | TCIRG1 | 10312 | 15 | 4 | 34 | |
| GSE60625 | TCIRG1 | 10312 | 0 | 3 | 8 | |
| GSE74703 | TCIRG1 | 10312 | 3 | 2 | 31 | |
| GSE74704 | TCIRG1 | 10312 | 8 | 1 | 11 | |
| TCGA | TCIRG1 | 10312 | 34 | 9 | 53 |
Total number of gains: 112; Total number of losses: 38; Total Number of normals: 338.
Somatic mutations of TCIRG1:
Generating mutation plots.
Highly correlated genes for TCIRG1:
Showing top 20/628 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TCIRG1 | TNRC6C-AS1 | 0.748078 | 3 | 0 | 3 |
| TCIRG1 | FAM20A | 0.745797 | 3 | 0 | 3 |
| TCIRG1 | RRP7A | 0.725082 | 4 | 0 | 4 |
| TCIRG1 | SSB | 0.723792 | 3 | 0 | 3 |
| TCIRG1 | SH3BP2 | 0.677988 | 4 | 0 | 3 |
| TCIRG1 | CMBL | 0.672224 | 3 | 0 | 3 |
| TCIRG1 | NEK8 | 0.670831 | 3 | 0 | 3 |
| TCIRG1 | TFRC | 0.668422 | 3 | 0 | 3 |
| TCIRG1 | NONO | 0.663207 | 3 | 0 | 3 |
| TCIRG1 | NLN | 0.662133 | 4 | 0 | 4 |
| TCIRG1 | SCARB1 | 0.659447 | 5 | 0 | 5 |
| TCIRG1 | FMNL2 | 0.658597 | 5 | 0 | 3 |
| TCIRG1 | RAPH1 | 0.656468 | 3 | 0 | 3 |
| TCIRG1 | BRI3 | 0.6557 | 3 | 0 | 3 |
| TCIRG1 | LAMB1 | 0.654701 | 4 | 0 | 4 |
| TCIRG1 | HOXD8 | 0.654032 | 4 | 0 | 3 |
| TCIRG1 | DHX58 | 0.650411 | 6 | 0 | 6 |
| TCIRG1 | FHL2 | 0.645926 | 4 | 0 | 4 |
| TCIRG1 | MICAL1 | 0.645696 | 6 | 0 | 6 |
| TCIRG1 | SLC28A3 | 0.644834 | 3 | 0 | 3 |
For details and further investigation, click here
