| Full name: toll like receptor adaptor molecule 1 | Alias Symbol: TRIF|TICAM-1|MGC35334|PRVTIRB | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 148022 | HGNC ID: HGNC:18348 | Ensembl Gene: ENSG00000127666 | OMIM ID: 607601 |
| Drug and gene relationship at DGIdb | |||
TICAM1 involved pathways:
Expression of TICAM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TICAM1 | 148022 | 213191_at | -0.5948 | 0.1185 | |
| GSE20347 | TICAM1 | 148022 | 213191_at | -1.0146 | 0.0000 | |
| GSE23400 | TICAM1 | 148022 | 213191_at | -1.0161 | 0.0000 | |
| GSE26886 | TICAM1 | 148022 | 213191_at | -0.3900 | 0.1871 | |
| GSE29001 | TICAM1 | 148022 | 213191_at | -0.9663 | 0.0002 | |
| GSE38129 | TICAM1 | 148022 | 213191_at | -0.7385 | 0.0007 | |
| GSE45670 | TICAM1 | 148022 | 213191_at | -0.4269 | 0.0396 | |
| GSE63941 | TICAM1 | 148022 | 213191_at | 0.0506 | 0.9123 | |
| GSE77861 | TICAM1 | 148022 | 213191_at | -0.5368 | 0.0073 | |
| GSE97050 | TICAM1 | 148022 | A_23_P376096 | -0.3379 | 0.3412 | |
| SRP007169 | TICAM1 | 148022 | RNAseq | -3.0744 | 0.0000 | |
| SRP008496 | TICAM1 | 148022 | RNAseq | -3.1663 | 0.0000 | |
| SRP064894 | TICAM1 | 148022 | RNAseq | -2.0861 | 0.0000 | |
| SRP133303 | TICAM1 | 148022 | RNAseq | -1.4307 | 0.0000 | |
| SRP159526 | TICAM1 | 148022 | RNAseq | -2.1209 | 0.0000 | |
| SRP193095 | TICAM1 | 148022 | RNAseq | -1.4512 | 0.0000 | |
| SRP219564 | TICAM1 | 148022 | RNAseq | -1.8348 | 0.0006 | |
| TCGA | TICAM1 | 148022 | RNAseq | 0.0114 | 0.8638 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by TICAM1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TICAM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TICAM1 | 148022 | 5 | 3 | 22 | |
| GSE20123 | TICAM1 | 148022 | 4 | 2 | 24 | |
| GSE43470 | TICAM1 | 148022 | 1 | 8 | 34 | |
| GSE46452 | TICAM1 | 148022 | 47 | 1 | 11 | |
| GSE47630 | TICAM1 | 148022 | 5 | 7 | 28 | |
| GSE54993 | TICAM1 | 148022 | 16 | 3 | 51 | |
| GSE54994 | TICAM1 | 148022 | 6 | 16 | 31 | |
| GSE60625 | TICAM1 | 148022 | 9 | 0 | 2 | |
| GSE74703 | TICAM1 | 148022 | 1 | 5 | 30 | |
| GSE74704 | TICAM1 | 148022 | 1 | 2 | 17 | |
| TCGA | TICAM1 | 148022 | 12 | 18 | 66 |
Total number of gains: 107; Total number of losses: 65; Total Number of normals: 316.
Somatic mutations of TICAM1:
Generating mutation plots.
Highly correlated genes for TICAM1:
Showing top 20/1077 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TICAM1 | SLK | 0.780131 | 6 | 0 | 6 |
| TICAM1 | GYS2 | 0.763531 | 8 | 0 | 8 |
| TICAM1 | ATG9B | 0.763172 | 4 | 0 | 4 |
| TICAM1 | VPS37B | 0.756036 | 7 | 0 | 7 |
| TICAM1 | DUSP5 | 0.75583 | 9 | 0 | 8 |
| TICAM1 | FCHO2 | 0.754433 | 3 | 0 | 3 |
| TICAM1 | SH3GL1 | 0.746871 | 9 | 0 | 8 |
| TICAM1 | SESN2 | 0.743323 | 4 | 0 | 4 |
| TICAM1 | C18orf25 | 0.741363 | 8 | 0 | 7 |
| TICAM1 | PSCA | 0.738422 | 8 | 0 | 8 |
| TICAM1 | RNF141 | 0.736089 | 7 | 0 | 6 |
| TICAM1 | SCNN1B | 0.736033 | 8 | 0 | 7 |
| TICAM1 | WWC1 | 0.733473 | 8 | 0 | 8 |
| TICAM1 | TJP3 | 0.732457 | 7 | 0 | 7 |
| TICAM1 | ABHD5 | 0.726838 | 8 | 0 | 8 |
| TICAM1 | TOM1 | 0.726823 | 8 | 0 | 7 |
| TICAM1 | MXD1 | 0.726273 | 10 | 0 | 8 |
| TICAM1 | ECM1 | 0.725207 | 9 | 0 | 8 |
| TICAM1 | VASN | 0.721882 | 4 | 0 | 4 |
| TICAM1 | IL36A | 0.721629 | 8 | 0 | 7 |
For details and further investigation, click here
