| Full name: vacuole membrane protein 1 | Alias Symbol: EPG3|TANGO5 | ||
| Type: protein-coding gene | Cytoband: 17q23.1 | ||
| Entrez ID: 81671 | HGNC ID: HGNC:29559 | Ensembl Gene: ENSG00000062716 | OMIM ID: 611753 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of VMP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VMP1 | 81671 | 1569003_at | -0.3168 | 0.4443 | |
| GSE26886 | VMP1 | 81671 | 1569003_at | -0.4753 | 0.4068 | |
| GSE45670 | VMP1 | 81671 | 1569003_at | 0.5363 | 0.0457 | |
| GSE53622 | VMP1 | 81671 | 14822 | 1.0135 | 0.0000 | |
| GSE53624 | VMP1 | 81671 | 14822 | 0.3385 | 0.0000 | |
| GSE63941 | VMP1 | 81671 | 1569003_at | 2.0552 | 0.0044 | |
| GSE77861 | VMP1 | 81671 | 1569003_at | 0.8788 | 0.0881 | |
| GSE97050 | VMP1 | 81671 | A_33_P3407925 | 1.9237 | 0.0465 | |
| SRP007169 | VMP1 | 81671 | RNAseq | 0.1075 | 0.7617 | |
| SRP008496 | VMP1 | 81671 | RNAseq | 0.3766 | 0.2701 | |
| SRP064894 | VMP1 | 81671 | RNAseq | 0.5371 | 0.0155 | |
| SRP133303 | VMP1 | 81671 | RNAseq | 1.4095 | 0.0000 | |
| SRP159526 | VMP1 | 81671 | RNAseq | -0.0080 | 0.9831 | |
| SRP193095 | VMP1 | 81671 | RNAseq | 0.5216 | 0.0025 | |
| SRP219564 | VMP1 | 81671 | RNAseq | 0.3889 | 0.2624 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by VMP1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of VMP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VMP1 | 81671 | 6 | 1 | 23 | |
| GSE20123 | VMP1 | 81671 | 6 | 1 | 23 | |
| GSE43470 | VMP1 | 81671 | 5 | 0 | 38 | |
| GSE46452 | VMP1 | 81671 | 32 | 0 | 27 | |
| GSE47630 | VMP1 | 81671 | 7 | 1 | 32 | |
| GSE54993 | VMP1 | 81671 | 2 | 5 | 63 | |
| GSE54994 | VMP1 | 81671 | 9 | 5 | 39 | |
| GSE60625 | VMP1 | 81671 | 4 | 0 | 7 | |
| GSE74703 | VMP1 | 81671 | 5 | 0 | 31 | |
| GSE74704 | VMP1 | 81671 | 5 | 1 | 14 | |
| TCGA | VMP1 | 81671 | 29 | 8 | 59 |
Total number of gains: 110; Total number of losses: 22; Total Number of normals: 356.
Somatic mutations of VMP1:
Generating mutation plots.
Highly correlated genes for VMP1:
Showing top 20/81 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VMP1 | TNC | 0.733818 | 4 | 0 | 4 |
| VMP1 | LOXL2 | 0.721496 | 3 | 0 | 3 |
| VMP1 | LPCAT1 | 0.697438 | 3 | 0 | 3 |
| VMP1 | TNFSF10 | 0.689069 | 3 | 0 | 3 |
| VMP1 | PTHLH | 0.682704 | 4 | 0 | 3 |
| VMP1 | AMIGO2 | 0.679777 | 3 | 0 | 3 |
| VMP1 | PXDN | 0.678304 | 3 | 0 | 3 |
| VMP1 | PLVAP | 0.675412 | 3 | 0 | 3 |
| VMP1 | SNX10 | 0.674716 | 4 | 0 | 4 |
| VMP1 | ERRFI1 | 0.668495 | 3 | 0 | 3 |
| VMP1 | AHR | 0.666892 | 3 | 0 | 3 |
| VMP1 | SLC30A7 | 0.651912 | 3 | 0 | 3 |
| VMP1 | GTSE1 | 0.644779 | 3 | 0 | 3 |
| VMP1 | CDC25B | 0.643048 | 3 | 0 | 3 |
| VMP1 | MMP1 | 0.642389 | 4 | 0 | 3 |
| VMP1 | MET | 0.633274 | 4 | 0 | 3 |
| VMP1 | CXCL1 | 0.632943 | 4 | 0 | 3 |
| VMP1 | LAMA3 | 0.624303 | 4 | 0 | 3 |
| VMP1 | FSCN1 | 0.62231 | 6 | 0 | 4 |
| VMP1 | ISG20L2 | 0.620691 | 4 | 0 | 3 |
For details and further investigation, click here
