WNT4

 

Full name: Wnt family member 4 Alias Symbol: WNT-4
Type: protein-coding gene Cytoband: 1p36.12
Entrez ID: 54361 HGNC ID: HGNC:12783 Ensembl Gene: ENSG00000162552 OMIM ID: 603490
Drug and gene relationship at DGIdb

 

WNT4 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa04919Thyroid hormone signaling pathway
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of WNT4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WNT4 54361 208606_s_at 0.4807 0.5552
GSE20347 WNT4 54361 208606_s_at -1.0454 0.0001
GSE23400 WNT4 54361 208606_s_at -0.5311 0.0001
GSE26886 WNT4 54361 208606_s_at -0.7027 0.0987
GSE29001 WNT4 54361 208606_s_at -0.7833 0.1944
GSE38129 WNT4 54361 208606_s_at -0.5553 0.1008
GSE45670 WNT4 54361 208606_s_at -0.3156 0.4661
GSE53622 WNT4 54361 37507 0.2713 0.0435
GSE53624 WNT4 54361 30946 -1.3615 0.0000
GSE63941 WNT4 54361 230751_at 0.5287 0.1038
GSE77861 WNT4 54361 1556689_a_at -0.0918 0.4485
GSE97050 WNT4 54361 A_33_P3321070 -0.0691 0.7382
SRP007169 WNT4 54361 RNAseq -3.2395 0.0000
SRP008496 WNT4 54361 RNAseq -2.0847 0.0135
SRP064894 WNT4 54361 RNAseq -1.1792 0.0083
SRP133303 WNT4 54361 RNAseq -0.8588 0.0071
SRP159526 WNT4 54361 RNAseq -1.0509 0.1054
SRP193095 WNT4 54361 RNAseq -0.6495 0.0029
SRP219564 WNT4 54361 RNAseq -1.0935 0.2014
TCGA WNT4 54361 RNAseq 0.2480 0.2270

Upregulated datasets: 0; Downregulated datasets: 5.  

 

Survival by WNT4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WNT4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WNT4 54361 0 5 25
GSE20123 WNT4 54361 0 4 26
GSE43470 WNT4 54361 2 6 35
GSE46452 WNT4 54361 5 1 53
GSE47630 WNT4 54361 8 3 29
GSE54993 WNT4 54361 2 1 67
GSE54994 WNT4 54361 11 4 38
GSE60625 WNT4 54361 0 0 11
GSE74703 WNT4 54361 1 4 31
GSE74704 WNT4 54361 0 0 20
TCGA WNT4 54361 9 23 64

Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.  

 

Somatic mutations of WNT4:

 

Generating mutation plots.

 

Highly correlated genes for WNT4:

 

Showing top 20/210 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WNT4CPNE30.635307604
WNT4UPK3B0.609777303
WNT4PSME10.606444303
WNT4C1orf1160.60222808
WNT4RARG0.600954706
WNT4MIOS0.597883605
WNT4SEMA3F0.596041706
WNT4IVL0.593961806
WNT4BLVRB0.5939706
WNT4LY6D0.592157907
WNT4RAB250.59065706
WNT4CES20.590434605
WNT4DHRS10.585838906
WNT4ALS2CL0.585135806
WNT4SNX160.581411403
WNT4EPS8L20.580952706
WNT4PRRG40.580633907
WNT4ZNF1850.579555907
WNT4MAPK130.578778704
WNT4SPINK50.578122705

For details and further investigation, click here