| Full name: follistatin | Alias Symbol: FS | ||
| Type: protein-coding gene | Cytoband: 5q11.2 | ||
| Entrez ID: 10468 | HGNC ID: HGNC:3971 | Ensembl Gene: ENSG00000134363 | OMIM ID: 136470 |
| Drug and gene relationship at DGIdb | |||
FST involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway |
Expression of FST:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FST | 10468 | 204948_s_at | 0.3255 | 0.7765 | |
| GSE20347 | FST | 10468 | 204948_s_at | 1.8715 | 0.0000 | |
| GSE23400 | FST | 10468 | 204948_s_at | 1.4651 | 0.0000 | |
| GSE26886 | FST | 10468 | 204948_s_at | 1.8806 | 0.0001 | |
| GSE29001 | FST | 10468 | 204948_s_at | 1.5697 | 0.0008 | |
| GSE38129 | FST | 10468 | 204948_s_at | 1.9139 | 0.0000 | |
| GSE45670 | FST | 10468 | 204948_s_at | 1.5556 | 0.0070 | |
| GSE53622 | FST | 10468 | 59828 | 1.9175 | 0.0000 | |
| GSE53624 | FST | 10468 | 59828 | 2.7469 | 0.0000 | |
| GSE63941 | FST | 10468 | 204948_s_at | -3.4788 | 0.0016 | |
| GSE77861 | FST | 10468 | 204948_s_at | 1.2622 | 0.0094 | |
| GSE97050 | FST | 10468 | A_23_P110531 | 2.0657 | 0.0867 | |
| SRP007169 | FST | 10468 | RNAseq | 4.5709 | 0.0000 | |
| SRP008496 | FST | 10468 | RNAseq | 4.4583 | 0.0000 | |
| SRP064894 | FST | 10468 | RNAseq | 1.6966 | 0.0000 | |
| SRP133303 | FST | 10468 | RNAseq | 2.4938 | 0.0000 | |
| SRP193095 | FST | 10468 | RNAseq | 3.2230 | 0.0000 | |
| SRP219564 | FST | 10468 | RNAseq | 0.8219 | 0.2398 | |
| TCGA | FST | 10468 | RNAseq | 0.4631 | 0.0140 |
Upregulated datasets: 14; Downregulated datasets: 1.
Survival by FST expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FST:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FST | 10468 | 2 | 12 | 16 | |
| GSE20123 | FST | 10468 | 2 | 12 | 16 | |
| GSE43470 | FST | 10468 | 1 | 12 | 30 | |
| GSE46452 | FST | 10468 | 1 | 27 | 31 | |
| GSE47630 | FST | 10468 | 2 | 16 | 22 | |
| GSE54993 | FST | 10468 | 8 | 1 | 61 | |
| GSE54994 | FST | 10468 | 5 | 17 | 31 | |
| GSE60625 | FST | 10468 | 0 | 0 | 11 | |
| GSE74703 | FST | 10468 | 1 | 9 | 26 | |
| GSE74704 | FST | 10468 | 2 | 5 | 13 | |
| TCGA | FST | 10468 | 10 | 45 | 41 |
Total number of gains: 34; Total number of losses: 156; Total Number of normals: 298.
Somatic mutations of FST:
Generating mutation plots.
Highly correlated genes for FST:
Showing top 20/933 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FST | FAM89A | 0.7659 | 3 | 0 | 3 |
| FST | ALPK2 | 0.738205 | 3 | 0 | 3 |
| FST | ADAMTS12 | 0.736476 | 7 | 0 | 7 |
| FST | MICAL1 | 0.728517 | 3 | 0 | 3 |
| FST | COL1A1 | 0.725286 | 10 | 0 | 10 |
| FST | TGFBI | 0.72313 | 11 | 0 | 11 |
| FST | FMNL2 | 0.722027 | 7 | 0 | 7 |
| FST | MFAP2 | 0.717144 | 10 | 0 | 9 |
| FST | SPON2 | 0.711769 | 3 | 0 | 3 |
| FST | MMP1 | 0.70985 | 12 | 0 | 11 |
| FST | MET | 0.70844 | 10 | 0 | 9 |
| FST | PTK7 | 0.702674 | 9 | 0 | 9 |
| FST | COL5A2 | 0.697705 | 11 | 0 | 10 |
| FST | CALCRL | 0.694387 | 3 | 0 | 3 |
| FST | LRRC8D | 0.692149 | 11 | 0 | 10 |
| FST | PDPN | 0.692094 | 9 | 0 | 8 |
| FST | TENM2 | 0.691553 | 6 | 0 | 6 |
| FST | FAP | 0.687972 | 10 | 0 | 10 |
| FST | SCYL1 | 0.686909 | 4 | 0 | 4 |
| FST | POSTN | 0.68662 | 12 | 0 | 12 |
For details and further investigation, click here
