| Full name: dedicator of cytokinesis 4 | Alias Symbol: FLJ34238|KIAA0716 | ||
| Type: protein-coding gene | Cytoband: 7q31.1 | ||
| Entrez ID: 9732 | HGNC ID: HGNC:19192 | Ensembl Gene: ENSG00000128512 | OMIM ID: 607679 |
| Drug and gene relationship at DGIdb | |||
DOCK4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway |
Expression of DOCK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOCK4 | 9732 | 205003_at | 0.0276 | 0.9753 | |
| GSE20347 | DOCK4 | 9732 | 205003_at | 0.3430 | 0.1254 | |
| GSE23400 | DOCK4 | 9732 | 205003_at | 0.1741 | 0.1948 | |
| GSE26886 | DOCK4 | 9732 | 205003_at | 1.5936 | 0.0001 | |
| GSE29001 | DOCK4 | 9732 | 205003_at | 0.1826 | 0.7348 | |
| GSE38129 | DOCK4 | 9732 | 205003_at | 0.2446 | 0.2952 | |
| GSE45670 | DOCK4 | 9732 | 205003_at | -0.6589 | 0.0280 | |
| GSE53622 | DOCK4 | 9732 | 20940 | 0.1209 | 0.1484 | |
| GSE53624 | DOCK4 | 9732 | 20940 | 0.1844 | 0.0257 | |
| GSE63941 | DOCK4 | 9732 | 205003_at | -4.8227 | 0.0001 | |
| GSE77861 | DOCK4 | 9732 | 244840_x_at | 0.0404 | 0.8228 | |
| GSE97050 | DOCK4 | 9732 | A_23_P59637 | 0.2046 | 0.4224 | |
| SRP007169 | DOCK4 | 9732 | RNAseq | 1.5308 | 0.0014 | |
| SRP008496 | DOCK4 | 9732 | RNAseq | 1.8072 | 0.0000 | |
| SRP064894 | DOCK4 | 9732 | RNAseq | 0.2947 | 0.3736 | |
| SRP133303 | DOCK4 | 9732 | RNAseq | 0.1824 | 0.3231 | |
| SRP159526 | DOCK4 | 9732 | RNAseq | 0.1053 | 0.6883 | |
| SRP193095 | DOCK4 | 9732 | RNAseq | 0.8359 | 0.0000 | |
| SRP219564 | DOCK4 | 9732 | RNAseq | 0.1380 | 0.7195 | |
| TCGA | DOCK4 | 9732 | RNAseq | -0.0706 | 0.4642 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by DOCK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOCK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOCK4 | 9732 | 10 | 2 | 18 | |
| GSE20123 | DOCK4 | 9732 | 11 | 2 | 17 | |
| GSE43470 | DOCK4 | 9732 | 7 | 1 | 35 | |
| GSE46452 | DOCK4 | 9732 | 8 | 1 | 50 | |
| GSE47630 | DOCK4 | 9732 | 7 | 4 | 29 | |
| GSE54993 | DOCK4 | 9732 | 3 | 8 | 59 | |
| GSE54994 | DOCK4 | 9732 | 12 | 5 | 36 | |
| GSE60625 | DOCK4 | 9732 | 0 | 0 | 11 | |
| GSE74703 | DOCK4 | 9732 | 7 | 1 | 28 | |
| GSE74704 | DOCK4 | 9732 | 7 | 2 | 11 | |
| TCGA | DOCK4 | 9732 | 37 | 16 | 43 |
Total number of gains: 109; Total number of losses: 42; Total Number of normals: 337.
Somatic mutations of DOCK4:
Generating mutation plots.
Highly correlated genes for DOCK4:
Showing top 20/240 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOCK4 | FOXL1 | 0.752767 | 3 | 0 | 3 |
| DOCK4 | AP5S1 | 0.744679 | 3 | 0 | 3 |
| DOCK4 | MMP3 | 0.70702 | 3 | 0 | 3 |
| DOCK4 | C12orf75 | 0.706628 | 3 | 0 | 3 |
| DOCK4 | MAN1A1 | 0.691803 | 10 | 0 | 10 |
| DOCK4 | CHST14 | 0.686978 | 3 | 0 | 3 |
| DOCK4 | YIPF5 | 0.685678 | 4 | 0 | 4 |
| DOCK4 | SMIM3 | 0.65415 | 5 | 0 | 4 |
| DOCK4 | TRHDE | 0.653037 | 4 | 0 | 3 |
| DOCK4 | TNFSF13B | 0.64499 | 6 | 0 | 5 |
| DOCK4 | SYT11 | 0.644444 | 6 | 0 | 5 |
| DOCK4 | TBX5-AS1 | 0.641497 | 4 | 0 | 3 |
| DOCK4 | S1PR1 | 0.639798 | 4 | 0 | 3 |
| DOCK4 | SH2B3 | 0.638124 | 8 | 0 | 7 |
| DOCK4 | ARHGAP18 | 0.637582 | 4 | 0 | 4 |
| DOCK4 | SDC3 | 0.62503 | 4 | 0 | 3 |
| DOCK4 | LOX | 0.623174 | 4 | 0 | 3 |
| DOCK4 | ATG2A | 0.622347 | 4 | 0 | 3 |
| DOCK4 | PLA2G15 | 0.620831 | 5 | 0 | 3 |
| DOCK4 | CSGALNACT2 | 0.615361 | 11 | 0 | 8 |
For details and further investigation, click here
