ELK4

 

Full name: ETS transcription factor ELK4 Alias Symbol: SAP1
Type: protein-coding gene Cytoband: 1q32.1
Entrez ID: 2005 HGNC ID: HGNC:3326 Ensembl Gene: ENSG00000158711 OMIM ID: 600246
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ELK4 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway

 

Expression of ELK4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ELK4 2005 225159_s_at 0.6768 0.0494
GSE20347 ELK4 2005 214831_at 0.4244 0.0000
GSE23400 ELK4 2005 214831_at 0.2926 0.0000
GSE26886 ELK4 2005 225159_s_at 0.6609 0.0201
GSE29001 ELK4 2005 214831_at 0.6985 0.0033
GSE38129 ELK4 2005 214831_at 0.3426 0.0004
GSE45670 ELK4 2005 225159_s_at 0.0521 0.7765
GSE53622 ELK4 2005 9990 0.4054 0.0000
GSE53624 ELK4 2005 50420 0.4922 0.0000
GSE63941 ELK4 2005 225159_s_at -0.3988 0.3851
GSE77861 ELK4 2005 225159_s_at 0.6275 0.0185
GSE97050 ELK4 2005 A_33_P3365010 0.4330 0.1657
SRP007169 ELK4 2005 RNAseq 1.2374 0.0015
SRP008496 ELK4 2005 RNAseq 1.0398 0.0000
SRP064894 ELK4 2005 RNAseq 0.4230 0.0647
SRP133303 ELK4 2005 RNAseq 0.3593 0.0050
SRP159526 ELK4 2005 RNAseq 0.7053 0.0054
SRP193095 ELK4 2005 RNAseq 0.4670 0.0000
SRP219564 ELK4 2005 RNAseq 0.7896 0.0306
TCGA ELK4 2005 RNAseq 0.2264 0.0005

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by ELK4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ELK4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ELK4 2005 11 0 19
GSE20123 ELK4 2005 11 0 19
GSE43470 ELK4 2005 7 0 36
GSE46452 ELK4 2005 3 1 55
GSE47630 ELK4 2005 14 0 26
GSE54993 ELK4 2005 0 6 64
GSE54994 ELK4 2005 15 0 38
GSE60625 ELK4 2005 0 0 11
GSE74703 ELK4 2005 7 0 29
GSE74704 ELK4 2005 5 0 15
TCGA ELK4 2005 43 5 48

Total number of gains: 116; Total number of losses: 12; Total Number of normals: 360.  

 

Somatic mutations of ELK4:

 

Generating mutation plots.

 

Highly correlated genes for ELK4:

 

Showing top 20/1712 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ELK4CENPBD10.820055303
ELK4PYCR20.807369303
ELK4CDCA20.79227303
ELK4SNAP470.762856303
ELK4MCMBP0.758115404
ELK4ZNF518B0.740842605
ELK4GPX70.733427505
ELK4MTBP0.731618404
ELK4NUP1530.717217403
ELK4LRRC580.717006505
ELK4MEX3B0.714606303
ELK4LRRC8C0.712718303
ELK4NOM10.711167404
ELK4RICTOR0.709701303
ELK4TXNDC120.70726505
ELK4DUS3L0.706783303
ELK4UROS0.706294303
ELK4NEDD10.705509606
ELK4NUF20.705242505
ELK4C1orf430.704631505

For details and further investigation, click here